SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NOVEL MANNICH BASE
S. Mohamed Rabeek, M. Sathyanarayanan and M. Seeni Mubarak*
ABSTRACT
In an effort to establish new candidates with improved antimicrobial activity of N-(4-chlorophenyl)-2,6-bis(3-nitrophenyl)-4-oxopiperidine-3-carboxamide was synthesized, characterized and evaluated for antimicrobial activity. The desired compounds was synthesized by the condensation of 4-chloroacetoacetanilide, 3-nitrobenzaldehyde with ammonium formate. Compound was characterized by IR, 1H-NMR, 13C- NMR and elemental analysis. They were also screened for antimicrobial activity against Klebsiella pneumonia, Staphylococcus auerus, Shigellady sentaeriae, Escheria coli, Pseudomonous aeruginosa, Streptococcus pneumonia and Proteus vulgaris.
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