AN UNUSUAL CAUSE OF NEPHROTIC SYNDROME IN A CHILD; DENSE DEPOSIT DISEASE
Srikanth Burri, Dr. Manjusha Yadla*, Swarnalatha Gowrishankar, Arun Chitale and PVSK Sharma
ABSTRACT
Common causes of nephrotic syndrome in children are minimal change disease,and focal segmental glomerulosclerosis. Though Membranoproloiferative glomerulonephritis I (MPGN) is one of the causes in Indian children, MPGN II, better known as dense deposit disease (DDD) is uncommon. Genetic factors play a significant role in the aetiopathogenesis of DDD. One such factor is CFH Tyr 402 His mutation. Herein we report one such case of dense deposit disease due to underlying CFH Y402 mutation, which responded partially to plasma infusion.
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