Abstract

Madhavi Surve*, Mayuresh Borkar, Om Kardile, Priyanka Chandorkar, Omkar Kadam and Dr. Shrutika Patil

ABSTRACT

The present research project aims to design, develop, and evaluate oral thin films (OTFs) incorporating Tinospora cordifolia (Guduchi) and Cinnamomum cassia (Cinnamon) extracts for their antidiabetic activity. The study focuses on creating a novel herbal-based drug delivery system that offers improved bioavailability, therapeutic efficacy, and safety. The project encompasses a comprehensive formulation process that begins with the careful selection of suitable excipients and herbal active ingredients, guided by extensive literature review and experimental validation. Extraction of the active phytoconstituents from Tinospora cordifolia and Cinnamomum cassia was carried out using standardized methods to ensure maximum yield and potency. These extracts were then incorporated into oral thin films through a solvent casting technique, followed by rigorous optimization to attain desirable film characteristics. Key physicochemical parameters such as film thickness, tensile strength, disintegration time, folding endurance, and surface pH were evaluated to ensure consistency, stability, and patient compliance. The films demonstrated promising properties that indicate potential for effective antidiabetic action via buccal administration, bypassing first-pass metabolism and enhancing drug absorption. The findings suggest that the developed oral thin film can serve as an innovative and efficient alternative for diabetes management, especially in populations seeking herbal and user-friendly therapeutic options.