Abstract

Uthman Ademola Yusuf*, Betty Banda, Mwewa Masamba, Michelo Miyoba, Aminat Adejoke Yusuf, Samuel Bolaji Mesole

ABSTRACT

Psidium Guajava has widely been seen to contain antihyperglycemic constituents. The study objective was to evaluate the antihyperglycemic effect of aqueous extract of Psidium Guajava in the liver of streptozotocin-induced diabetic male Wistar rats. Thirty male Wistar rats weighing between 180-220 g were randomly selected into five groups (6 per cage); normal control, diabetic control, diabetic +metformin, diabetic +guava and guava leaves only group. Diabetes mellitus was induced using a single intraperitoneal dose of streptozotocin (70mg/kg BW) and established a steady state of hyperglycemia after 72hours. The aqueous extract of Psidium Guajava and metformin of 200 mg/kg BW was administered orally using orogastric cannula daily for a period of 4 weeks. The results showed that the Diabetic +Guava and diabetic + metfor min group’s body weight was statistically significant when compared to the diabetic group (P<0.05). The blood glucose in diabetic + guava and Diabetic + metformin group was normoglycemic by week 4 and it was statistically significant when compare to diabetic group (P<0.05). The histological findings of the normal control and guava leaves only groups showed normal histoarchitecture, diabetic group showed high degree of disorganization in the histoarchitecture with many necrotic hepatocytes and a lot of collagen accumulation. The diabetic+Guava and diabetic+Metformin group showed little disorganization in their histoarchitecture and had both healthy and necrotic hepatic tissues present with little accumulation of collagen. Psidium Guajava are able to lower elevated blood glucose levels and ameliorate the effects of STZ on the liver morphology.