ANTITUMOR POTENIAL OF MANGANESE NANOPARTICLES
Dr. Eman Abuheiba*, Sawsan M. El-Sonbaty, Nahed Abdel-Samed and Eman Kandil
ABSTRACT
This study aimed to evaluate the antitumor activity of manganese nanoparticles in vitro and in vivo in the management of hepatocellular carcinoma induced in rats. MnNPs were characterized by means of transmission electron microscopy TEM and MnNPs nanoparticles are of size range between 32.67-190.1 nm. In vitro study of Manganese nanoparticles on HepG2 revealed IC50 of 21.5mM .The in vivo efficacy of manganese nanoparticles was evaluated by measuring the antioxidant activities such as superoxide dismutase activity SOD and malondialdehyde level MDA against oxidative stress caused by diethylnitrosamine (DEN) in rates liver tissues. This treatment significantly improved the alanine aminotransferase (ALT) activity and total protein compared to DEN group. Results showed that manganese nanoparticles MnNPs were effective in treatment of HCC induced by diethylnitrosamine (DEN) in rats. So manganese nanoparticles MnNPs can serve as a good therapeutic agent for the treatment of hepatocellular carcinoma, and deserve further studies in the future.
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