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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 5.922

ICV : 78.6

Abstract

ANTITUMOR POTENIAL OF MANGANESE NANOPARTICLES

Dr. Eman Abuheiba*, Sawsan M. El-Sonbaty, Nahed Abdel-Samed and Eman Kandil

ABSTRACT

This study aimed to evaluate the antitumor activity of manganese nanoparticles in vitro and in vivo in the management of hepatocellular carcinoma induced in rats. MnNPs were characterized by means of transmission electron microscopy TEM and MnNPs nanoparticles are of size range between 32.67-190.1 nm. In vitro study of Manganese nanoparticles on HepG2 revealed IC50 of 21.5mM .The in vivo efficacy of manganese nanoparticles was evaluated by measuring the antioxidant activities such as superoxide dismutase activity SOD and malondialdehyde level MDA against oxidative stress caused by diethylnitrosamine (DEN) in rates liver tissues. This treatment significantly improved the alanine aminotransferase (ALT) activity and total protein compared to DEN group. Results showed that manganese nanoparticles MnNPs were effective in treatment of HCC induced by diethylnitrosamine (DEN) in rats. So manganese nanoparticles MnNPs can serve as a good therapeutic agent for the treatment of hepatocellular carcinoma, and deserve further studies in the future.

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