World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN (O) : 2455-3301
ISSN (P) : 3051-2557
IMPACT FACTOR: 7.533

ICV : 78.6

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SJIF Impact Factor: 7.533

Abstract

UV METHODS FOR THE SIMULTANEOUS DETERMINATION OF DAPAGLIFLOZIN PROPANEDIOL MONOHYDRATE AND BISOPROLOL FUMARATE IN COMBINED PHARMACEUTICAL FORMULATION

S. Arunprasath*, Dr. T. Vetrichelvan, Dr. S. M. Murugan

ABSTRACT

A simple, rapid, accurate, precise, and economical UV spectrophotometric “simultaneous equation method (Vierordt’s Method)” for the determination of Dapagliflozin Propanediol Monohydrate (DAPA) and Bisoprolol Fumarate (BISO) in a combined tablet dosage form using the simultaneous equation method has been developed. Materials and Methods: The method is based on the simultaneous equations for analysis of both the drugs using 0.1N HCl and further diluted with methanol as a solvent. DAPA has absorbance maxima at 224 nm and BISO has absorbance maxima at 264 nm in Methanol. Results: The linearity was obtained in the concentration range of 4–20 μg/ml and 2–10 μg/ml for DAPA and BISO, respectively. The concentrations of the drugs were determined by using the simultaneous equations method. The mean recovery was 99.97 and 99.92 for DAPA and BISO, respectively. Conclusion: The method was found to be simple, accurate, and precise and was applicable for the simultaneous determination of DAPA and BISO in the pharmaceutical tablet dosage form. The results of analysis have been validated statistically and by recovery studies.

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