World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN (O) : 2455-3301
ISSN (P) : 3051-2557
IMPACT FACTOR: 7.533

ICV : 78.6

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Abstract

A COMPARATIVE CLINICAL STUDY TO EVALUATE THE EFFICACY OF SAHACHARADI KASHAYA WITH VASAGUDUCHYADI KASHAYA PRECEDED BY SAHACHARADI TAILA MATRA BASTI IN SIRAJA GRANTHI VIS-À-VIS VARICOSE VEINS

Dr. Lalita Suranagi*, Dr. Ananta S. Desai, Dr. Mythrey R.C.

ABSTRACT

Background: Sir?ja Granthi, a V?tapradh?na Vy?dhi, can be correlated with varicose veins, a chronic venous disorder of dilated, elongated, tortuous superficial veins caused by valvular incompetence. It presents with pain, heaviness, edema, itching, pigmentation and reduced quality of life. Conventional management gives symptomatic relief but carries risks of recurrence and procedure-related complications. M?tr? Basti and V?tahara formulations may offer a safe, economical alternative. Objective: To compare the efficacy of Sahachar?di Ka??ya with V?s?gud?cy?di Ka??ya, each preceded by Sahachar?di Taila M?tr? Basti, in Sir?ja Granthi (uncomplicated varicose veins, CEAP C1–C4). Methods: Forty-four patients were registered, and 42 completed the study (21 per group). All received Sahachar?di Taila M?tr? Basti (72 ml) for 7 days. Group A then received Sahachar?di Ka??ya and Group B received V?s?gud?cy?di Ka??ya, 20 ml with an equal quantity of water twice daily before food for 30 days. Assessments were made on Day 0, Day 8, Day 38 and Day 68 (one-month follow-up) using the Visual Analogue Scale (VAS), Venous Clinical Severity Score (VCSS), and grading of Kandu and D?ha. Data were analysed with the Wilcoxon signed rank test, Mann–Whitney U test and Chi-square test. Results: Both groups showed statistically significant improvement in pain and modest improvement in VCSS. Group B showed a higher percentage improvement in pain (30.56% vs 27.03% at Day 38), but the intergroup difference was not statistically significant (p>0.05). Kandu showed no significant change owing to its low baseline prevalence, and D?ha was absent in all participants. M?tr? Basti was well tolerated and no adverse effects were recorded. Conclusion: Both protocols were safe and effective in uncomplicated Sir?ja Granthi (CEAP C1–C4), with no statistically significant difference between them.

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