Abstract

*Dr. Niranjana Krishnan, Dr. Sanila V. K.

ABSTRACT

Background: Dhanadanayanadi Kashaya is a classical polyherbal decoction documented in the Sahasrayoga (Kashaya Prakarana), traditionally indicated for the management of Vata rogas (neurological and neuromuscular disorders), specifically Ardita (facial paralysis/Bell's palsy) and Akshepaka (convulsive disorders or tremors). Aim: This review systematically analyses the classical Ayurvedic pharmacodynamics (Rasa, Guna, Virya, Vipaka, Doshakarma) of its 14 individual herbal components, delineates their known chemical profiles, maps their pharmacokinetic behaviour (ADME), and proposes an integrative multi-target mechanism of action. Results: The formulation demonstrates a predominant combination of Katu (pungent), Tikta (bitter), and Kashaya (astringent) Rasas; Ushna (hot potency) Virya; and Laghu (light), Ruksha (dry), Tikshna (sharp), and Sukshma (subtle) Gunas. Systemic integration of these properties resolves Srotorodha (microchannel blockages) and pacifies Avarana Vata (obstructed neural signalling). Concurrently, modern pharmacological data indicate that the bioactive constituents (e.g., piperine, gingerols, bonducin, plumbagin, alpha\beta-asarone) exert significant neuroprotective, anti-neuroinflammatory, and bio-enhancing effects. Conclusion: Dhanadanayanadi Kashaya acts through a bidirectional axis: resolving metabolic deficits (Agnimandya and Ama) at the gut level while simultaneously crossing the blood-brain barrier to attenuate neuroinflammatory damage and stabilise synaptic transmission.