Abstract

*Dr. Nidhi Bhawsar, Prof. (Dr.) Jitesh Kumar Panda, Prof. (Dr.) Ashish Mehta

ABSTRACT

Background: Menopause is a physiological transition characterized by permanent cessation of menstruation due to ovarian follicular depletion and declining estrogen levels. The associated vasomotor, psychological, musculoskeletal, and urogenital symptoms substantially impair the quality of life. In Ayurveda, these manifestations are correlated with Rajonivrittijanya Lakshanas, primarily resulting from Vata predominance secondary to Dhatukshaya. Although hormone replacement therapy remains the standard treatment, its long-term use is associated with significant adverse effects, highlighting the need for safe and effective alternative therapies. Nasya Karma, one of the Panchakarma procedures, is considered beneficial in disorders involving the head and central nervous system and may exert neuroendocrine effects. Amlakyadi Ghrita and Shatavari Ghrita possess Rasayana, Vata-Pitta Shamaka, antioxidant, and phytoestrogenic properties that may alleviate menopausal symptoms. A randomized open-labelled controlled clinical study will be conducted on 42 postmenopausal women divided equally into two groups of 21 each. Group A will receive Amlakyadi Ghrita Nasya and Group B will receive Shatavari Ghrita Nasya. The primary outcome will be change in serum estradiol levels, while secondary outcomes include menopausal symptom scores. The study is expected to provide scientific evidence supporting Amlakyadi Ghrita Nasya as a safe, effective, and evidence-based Ayurvedic intervention for postmenopausal syndrome. Methodology: 42 patients of Rajonivritti will be selected on the basis of selection criteria. All patients will be divided into two groups. Each group having 21 patients. In group A patients Amlakyadi ghrita nasya will be given for 7 sittings in between 7 to 21 days and in group B patients Shatavari ghrita nasya will be given for7 sittings in between 7 to 21 days. Observations will be done on the basis of before and after subjective and objective parameters and clinical investigations.