World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN (O) : 2455-3301
ISSN (P) : 3051-2557
IMPACT FACTOR: 7.533

ICV : 78.6

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Abstract

POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME ASSOCIATED WITH ECLAMPSIA AND INTRAUTERINE FETAL DEMISE: A CASE REPORT AND LITERATURE REVIEW

*Samia Dagdag, Doaa Riali, Rim Laaboudi, Samir Bargach

ABSTRACT

Posterior reversible encephalopathy syndrome (PRES) is a rare clinico-radiological syndrome that may occur in the setting of hypertensive disorders of pregnancy, particularly severe preeclampsia and eclampsia. It is characterized by acute neurological manifestations such as seizures, headache, visual disturbances, confusion, and characteristic neuroimaging abnormalities related mainly to vasogenic cerebral edema. We report the case of a 17-year-old primigravida with an unsupervised pregnancy estimated at 33 weeks of gestation, admitted to the obstetric emergency department for an eclamptic seizure. Obstetric ultrasound confirmed intrauterine fetal demise. Laboratory investigations showed significant proteinuria, thrombocytopenia, elevated liver enzymes, increased lactate dehydrogenase, and mild renal impairment, consistent with severe preeclampsia. Vaginal delivery resulted in the birth of a male fetus weighing 1655 g. Cerebral computed tomography performed after obstetric management revealed findings suggestive of PRES. The patient received multidisciplinary management with close monitoring, blood pressure control, and anticonvulsant therapy, followed by complete neurological recovery without residual deficits. This case highlights the importance of considering PRES in pregnant patients presenting with seizures or other neurological symptoms in the context of preeclampsia or eclampsia.

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