Abstract

Amit Patel*, Dr. Jeevan Patel, Dr. Sudha Vengurlekar, Dr. Rajesh Nagar

ABSTRACT

The present study aimed to develop and evaluate extended-release pellets of Pindolol using solution layering technology and polymer coating techniques. Pindolol, a non-selective beta-blocker with a short biological half-life, requires frequent dosing, which may reduce patient compliance. To overcome this limitation, extended-release pellets were prepared using sugar spheres as inert cores, followed by drug layering and functional coating with Ethyl Cellulose and Hydroxypropyl Methylcellulose (HPMC). The prepared pellets were evaluated for physicochemical properties, flow characteristics, hardness, dissolution behaviour, and release kinetics. The optimized formulation demonstrated sustained drug release up to 20 hours and exhibited satisfactory pharmaceutical properties. Drug release followed zero-order kinetics with diffusion-controlled release behaviour according to the Higuchi model. The study concludes that extended-release pellet formulation of Pindolol can improve therapeutic efficacy and patient compliance.