PHARAMACEUTICO - ANALYTICAL STUDY OF KAMADUGHA RASA EFFERVESCENT GRANULES: A NOVEL DOSAGE FORM
Dr. Deepa Sidagond*, Dr. P. R. Deshpande, Dr. Pratibha Muranal
ABSTRACT
Background: Kamadugha Rasa is a classical Ayurvedic herbo-mineral formulation widely indicated in Amlapitta (hyperacidity), Pittaja disorders, gastritis and peptic irritation. Conventionally available as tablets or powder form. Patient compliance may be reduced due to taste, swallowing difficulty, and delayed onset. Effervescent granules offer rapid dispersion, improved palatability, and faster action. Aim: To develop and a novel dosage form of Kamadugha Rasa Effervescent Granules and evaluate its Pharamaceutico-analytical parameters. Methods: Kamadugha Rasa was prepared as per classical references and blended with citric acid, tartaric acid, sodium bicarbonate, sweetener, and flavouring agents to formulate effervescent granules by dry granulation method. Analytical parameters such as organoleptic characters, angle of repose, bulk density, tapped density, Carr’s index, Hausner ratio, moisture content, effervescence timeand stability were evaluated. Results: The prepared granules showed satisfactory flow properties, rapid effervescence, low moisture content, and good stability. The formulation was palatable and dispersed in water within 2 minutes. Conclusion: Kamadugha Rasa Effervescent Granules may be considered a patient-friendly innovative dosage form with potential rapid therapeutic action in acid-peptic disorders.
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