Abstract

Dr. Dindi Arun Kumar*, Dharamsoth Pavithrasena, Madas Kejiya, Atmakuri Harshini, Humera Soheb, Dr. N. Srinivas

ABSTRACT

Chronic kidney disease (CKD) is widely prevalent and increasingly common globally, currently standing as the seventh most significant contributor to mortality worldwide. Probiotics have become a safe and affordable treatment option for many chronic illnesses. Probiotic supplementation has been shown to alter the microbiota composition in the context of chronic kidney disease (CKD),[9] lowering inflammation and the production of uremic toxins. The aim and objective of the study to evaluate the impact of probiotics on progression of CKD by monitoring changes in Serum Creatinine and Urea over six months. The study was designed a prospective observational single centre study by the conduct of 6 months a period with100 subjects of population size. The result of the study on effect of probiotics on slowing the progression of chronic kidney disease about the highest number of patients fall in the age 70-79 i.e., (33%), male patients make up majority (61%) and The highest Patients were under stage 1 (61%), It presents both mean ± standard deviation (SD) and median values for each time point. Creatinine levels decreased over time, from initial to final, both in terms of mean and median. eGFR values increased progressively from the initial stage to the final stage. Standard deviation is quite high at all stages, indicating a wide variation in uric acid levels among subjects. The study concludes that provides compelling preliminary evidence that probiotics may play a valuable role in slowing the progression of Chronic Kidney Disease by improving renal biomarkers and offering a safe, well-tolerated adjunct to conventional therapy. While further high-quality research is necessary to establish clinical guidelines, this study sets the groundwork for the incorporation of gut microbiota-targeted therapies into standard nephrology practice. The evolving understanding of the gut-kidney axis opens up new horizons for managing CKD more effectively and holistically.