World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN (O) : 2455-3301
ISSN (P) : 3051-2557
IMPACT FACTOR: 7.533

ICV : 78.6

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SJIF Impact Factor: 7.533

Abstract

THE MODERN PATHOPHYSIOLOGY OF OBESITY AND ITS PRECISE HISTORICAL CORRELATION IN MADHAVA NIDANA AND CHARAKA SAMHITA

Prof. Dr. Kunwar Ratnesh Singh*, Dr. Khushabu Singh

ABSTRACT

Obesity has emerged as the premier global health challenge of the 21st century, transcending its perception as a cosmetic concern to become a complex metabolic pandemic. Driven by an 'obesogenic environment,' it leads to a state of chronic energy surplus. This article demonstrates that the modern Leptin Resistance Theory finds a precise historical correlation in the Ayurvedic concepts of Margavarodha (channel obstruction) and Agnivaishamya (metabolic disparity). Specifically, we explore the paradox of Tivra Jatharagni (intense gastric fire) paired with Manda Medodhatvagni (sluggish fat metabolism) as the ancient explanation for modern metabolic derangement and 'starvation signaling'.

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