Abstract

Owais Mohd Qureshi, Tushar Chaudhary, Tarun Parashar*

ABSTRACT

Wound healing is a vital biological process involving tissue repair and regeneration. Natural healing is often slow and prone to infection, necessitating effective topical interventions. Argyreia nervosa is a traditional medicinal plant known for its potent antiseptic and anti-inflammatory properties. Objectives: This study aims to formulate and evaluate a stable Oil-in-Water (O/W) herbal cream utilizing the ethanolic leaf extract of Argyreia nervosa for enhanced wound management. Methods: The extract was prepared via cold maceration. An O/W cream was formulated using a base of beeswax, liquid paraffin, borax, and methylparaben. The formulation was evaluated for pH, spreadability, homogeneity, viscosity, and stability under accelerated conditions (40°C). Results: The cream demonstrated a smooth consistency, excellent spreadability, and a skin-compatible pH of 6.4. Accelerated stability studies confirmed no phase separation or physical degradation over three months. Phytochemical analysis confirmed the presence of tannins and flavonoids, which are essential for collagen synthesis and rapid epithelialization. Conclusion: The developed Argyreia nervosa cream is a stable, cost-effective, and safe natural alternative to synthetic wound care products, supporting its clinical application in dermatological therapy.