Abstract

Ahmad Kazimov*, Irada Aliyeva, Sabina Mashadiyeva-Bayramova, Parvin Zulfugarova, Rubaba Guliyeva, Konul Ismayilova

ABSTRACT

Endocrine factors play a central role in the regulation of cellular physiology by coordinating metabolic, molecular, vascular, mitochondrial, and adaptive responses required for physiological homeostasis. This narrative review analyzes contemporary scientific evidence on the interaction between hormonal regulation and cellular function. Particular attention is given to receptor-mediated signaling pathways, insulin-dependent metabolic control, thyroid hormone–mediated bioenergetics, glucocorticoid-related stress adaptation, adipokine activity, endothelial regulation, mitochondrial function, oxidative balance, neuroendocrine integration, and epigenetic mechanisms. Current data indicate that endocrine regulation extends beyond classical hormonal effects and involves complex interactions among the nervous, immune, metabolic, and genetic systems. Disturbances in these endocrine-cellular mechanisms contribute to the development of metabolic syndrome, diabetes mellitus, cardiovascular disorders, obesity, chronic inflammation, neurodegenerative diseases, and aging-related cellular dysfunction. The integration of endocrinology with molecular and cellular physiology provides a deeper understanding of both normal adaptation and disease pathogenesis. Future multidisciplinary research combining molecular biology, bioinformatics, imaging technologies, and computational physiology may support the development of more precise diagnostic and therapeutic approaches in modern medicine.