Abstract

Dr. Prahlad Kumar Prajapati*, Dr. Umesh Kumar Sapra

ABSTRACT

Non-Alcoholic Fatty Liver Disease (NAFLD) is a growing global health concern characterized by excessive fat accumulation in the liver without significant alcohol consumption. It encompasses a spectrum ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), potentially progressing to cirrhosis and hepatocellular carcinoma. Modern therapeutic options for NAFLD are limited and primarily focus on lifestyle modification, highlighting the need for effective alternative treatments. Ayurveda, the ancient Indian system of medicine, offers a holistic approach to liver disorders, with several classical formulations reputed for their hepatoprotective and metabolic regulatory effects. Among these, Sudarshan Ghanvati and Arogyavardhani Vati have been traditionally employed for managing liver dysfunction and associated metabolic imbalances. This review compares the efficacy, pharmacodynamics, and clinical applications of Sudarshan Ghanvati and Arogyavardhani Vati in the management of NAFLD. Sudarshan Ghanvati, known for its Deepana (digestive stimulant), Pachana (digestive), and Pittashamak (anti-inflammatory) properties, aids in improving metabolism and reducing hepatic inflammation. Arogyavardhani Vati, containing a combination of herbs and mineral preparations, exhibits potent hepatoprotective, antioxidant, and lipid-lowering effects. Both formulations contribute to detoxification and metabolic homeostasis, albeit through differing mechanisms. By analyzing classical texts, clinical studies, and pharmacological data, this review highlights their therapeutic potential and safety profiles. It suggests that integrating these Ayurvedic formulations could provide a complementary approach to NAFLD management, warranting further clinical trials for standardized protocols and validation.