Abstract

Dr. Ashwini H.*, Dr. Usha M. (Ayu)

ABSTRACT

Background: Hyperlipidaemia is a prevalent metabolic disorder associated with obesity and cardiovascular diseases. In Ayurveda, it correlates with Medoroga (Sthaulya) arising from Kapha–Meda Dushti and impaired Agni. Medohara Rasa, a classical Kharaliya Rasayana described in Rasa Kamadhenu, is traditionally indicated for Medoroga. Due to the involvement of herbo-mineral components, pharmaceutico-analytical standardization is essential to ensure safety, stability, and therapeutic reliability. Materials and Methods: Medohara Rasa was prepared following classical procedures involving extraction of Parada from Hingula, Shodhana of Parada and Gandhaka, preparation of Kajjali, addition of Vidanga Choorna, and Bhavana with Arka Dugdha. Evaluation was carried out using classical Ayurvedic tests and modern analytical techniques including physicochemical analysis, X-ray diffraction (XRD), scanning electron microscopy with energy-dispersive spectroscopy (SEM-EDS), Fourier transform infrared spectroscopy (FTIR), particle size analysis, and HPTLC. Results: The formulation exhibited blackish-green colour, near-neutral pH, low ash values, and acceptable moisture content. XRD confirmed the presence of a stable mercuric sulphide (HgS) phase with absence of free mercury. SEM-EDS demonstrated mercury and sulphur as major elements. Particle size analysis revealed nanosized particles, suggesting enhanced bioavailability. FTIR and HPTLC identified bioactive functional groups and phytoconstituents such as embelin and polyphenols, associated with lipid metabolism. Conclusion: Pharmaceutico-analytical evaluation confirmed Medohara Rasa as a stable, safe, and standardized formulation with properties supporting its traditional use in Medoroga and hyperlipidaemia, providing a foundation for further pharmacological and clinical studies.