Abstract

Dr. Ambika*, Dr. Ravi R. Chavan, Dr. Lalitha

ABSTRACT

Background: Rasashastra, a specialized branch of Ayurveda, focuses on potent mineral formulations, with Kupipakwa Rasayana valued for stability and rapid action. The rising burden of chronic kidney disease necessitates safer nephroprotective agents. Hingulad Rasa Sindoora is one such classical formulation with potential renal protective action. Objectives: The present study aimed to evaluate the nephroprotective potential of Hingulad Rasa Sindoora against gentamicin-induced renal toxicity in Wistar albino rats through experimental assessment of renal biochemical and organ parameters. Methodology: Hingulad Rasa Sindoora was prepared and standardized prior to experimentation. Nephroprotective activity was evaluated in Wistar albino rats using a gentamicin-induced nephrotoxicity model. Animals were divided into normal control, gentamicin control, and treatment groups receiving Hingulad Rasa Sindoora and Hingulad Rasa Sindoora with Guduchi Swarasa. Renal toxicity was induced by gentamicin administration, followed by oral treatment with the test drugs. Nephroprotective efficacy was assessed by evaluating renal biochemical parameters, along with changes in body weight and organ weights. Data were statistically analyzed to determine the protective effect of Hingulad Rasa Sindoora. Results: Hingulad Rasa Sindoora was successfully prepared and analytically confirmed as HgS with characteristic physicochemical properties. Gentamicin induced significant nephrotoxicity, evidenced by elevated serum urea and creatinine levels. Treatment with Hingulad Rasa Sindoora significantly reduced these parameters (p < 0.05), while the combination with Guduchi Swarasa showed moderate improvement, Conclusion: Hingulad Rasa Sindoora is a safe, stable, and potent Kupipakwa Rasayana. demonstrated significant nephroprotective activity against gentamicin-induced renal toxicity by improving renal biochemical parameters in Wistar albino rats. The findings support its potential role as a renoprotective agent, warranting further experimental and clinical evaluation.