World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN (O) : 2455-3301
ISSN (P) : 3051-2557
IMPACT FACTOR: 7.533

ICV : 78.6

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Abstract

EVALUATION OF HAIR GROWTH PROMOTING POTENTIAL OF DURDHURADI TAILA THROUGH MODULATION OF 5Α-REDUCTASE GENE EXPRESSION

Akarsha Krishna S.*, Ashwin Kumar S. Bharati

ABSTRACT

Introduction: Hair plays a significant role in physical appearance, personal identity, cultural expression, and psychological well-being. Hair loss (alopecia) often results in embarrassment, reduced self-confidence, social withdrawal, and impaired quality of life. Beyond aesthetics, scalp hair provides protection against ultraviolet (UV) radiation, temperature extremes, and environmental irritants. Loss of hair increases scalp vulnerability to sunburn, sensitivity, and injury. Methods: Alopecia is defined as partial or complete loss of hair from normally hairy areas, most commonly the scalp. Major types include androgenic alopecia, alopecia areata, and chemotherapy-induced alopecia. Androgenic alopecia is the most prevalent, affecting nearly 50% of men and women, with higher incidence in men aged 30–50 years. In men, hair loss begins at the temples and vertex, while women show diffuse thinning over the crown.[1] Results: The condition is genetically determined and androgen-dependent. Testosterone is converted to dihydrotestosterone (DHT) by the enzyme 5α-reductase. DHT shortens the hair growth cycle, causes follicular miniaturization, and results in progressive thinning and hair loss. Modern lifestyle factors such as chemical treatments, dyes, gels, and excessive styling further aggravate hair fall. Discussion: Ayurvedic texts like the Sushruta Samhita caution against toxic scalp applications. Traditional formulations such as Durdhuradi Taila, recommended for kesha chyuti, are believed to nourish the scalp, strengthen hair roots, and promote regrowth. Effective management of alopecia requires understanding its biological mechanisms, avoiding harmful hair practices, and adopting holistic therapeutic approaches for optimal scalp and hair health.[2]

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