World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN (O) : 2455-3301
ISSN (P) : 3051-2557
IMPACT FACTOR: 7.533

ICV : 78.6

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SJIF Impact Factor: 7.533

Abstract

ANTI-EPILEPTIC ACTIVITY OF SARVAAPSMARAHARA RASA AGAINST PTZ. INDUCED EPILEPSY IN SWISS ALBINO MICE

*Dr. Sajid Rajasaheb Gaddanakeri, Dr. Prakash R. Deshpande, Dr. Pavan K. Kulkarni

ABSTRACT

Objective: The present study was designed to investigate the anti-epileptic activity of Sarvaapasmarahara rasa against Pentylene tetrazole (PTZ) induced epilepsy in Swiss albino mice. Materials and Methods: The Sarvaapasmarahara rasa was screened for its antiepileptic activity against Pentylene tetrazole (PTZ) induced epilepsy. The formulation was given orally at the doses of 125 mg/day for 15 consecutive days prior to the induction of seizure. The protection action against PTZ induced seizure was evaluated by behavioral paradigm. Results: In Pentylene tetrazole induced epilepsy model, Sarvaapasmarahara rasa at 125mg/day treated group showed significant increase in onset of action and decrease in death latency, number of convulsions, number of Straub's tail, duration of convulsions, jerking, tonic, clonic, duration of Stupor and Straub's tail was observed. Conclusion: Present study shows that the potent Antiepileptic role of Sarvaapasmarahara rasa on Swiss albino mice showed significant changes in behavioral paradigm. Further studies are required to elucidation the potent action of Sarvaapasmarahara rasa on treatment of epilepsy.

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