Abstract

*Vd. Chitra Karekar, Vd. Vinodini Payghan, Vd. Vipin Atram

ABSTRACT

The central nervous system, which is made up of the brain, spinal cord, and other major organs, is the principal organ of the human body. The most prevalent type of dementia, Alzheimer’s disease, is a neurological ailment that affects the older population and progresses irreversibly. By 2030, there will be approximately 1 billion people on the planet, up from 420 million in 2000, and with an increase in the percentage of elderly people from 7% to 12%. The cause of AD is yet unknown. The pathophysiology of AD includes low levels of the neurotransmitter Ach, aggregation of the amyloid beta peptide, accumulation of hyperphosphorylated tau protein, dyshomeostasis of biometals, oxidative stress, mitochondrial dysfunction, and neuroinflammation. The slow and steady decline in memory that affects language, personality, or cognitive control is the result of all these variables. There is no reliable diagnostic procedure; a brain autopsy is the only way to make a conclusive diagnosis of AD. The review indicates that Ayurvedic drugs like Brahmi, Mandookaparni, Shankhapushpi, Jyotishmati, Ashwagandha, Jatamansi, Madhuyashti, and Guduchi have the potential to provide a significant improvement in the memory and learning capacity of the elderly suffering from AD. All these drugs improve the brain functions and also the sensory and motor systems as a result of their medhyaproperties and thereby can help in the management of various cognitive disorders, mainly AD.