Abstract

Dr. Aditi Sarnopant*, Dr. Vinayak Joshi, Dr. Mangesh Udmale

ABSTRACT

Aim: To evaluate the effect of Varuni m adya sevan on fat metabolism insight of both modern bio medics as well as ayurveda theories and substantiate the traditional claims through classical references and also with the documented case studies. Background: Chronic alcohol consumption specially in unregulated manner palys significant role in the development of metabolic disorders like fatty liver, Obesity, dyslipidemia. Ayurved classic mentions the excessive madya seven specially the alcohol from Varuni varga is the causative factor of medovaha sro tas dushti. Particulary emphasizing Varuni Madya for its specific vitiation of particular doshas. Methods: A structured Literature review was carried out using the guidelines provided by PRISMA. Textual analysis of ayurvedic classics was combines with mode rn biomedical research evidences. Relevant case studies are examined for the clinical correlation. Review Result: in ayurveda describes Varunu Madya as agrivation Kapha dosh and pitta dosha also weakens the agni and causing the ama formation which ultimate ly Causes the medoroga, In other hand Modern Evidens supports the role of alcoholism in increase in lipid accoumulation causing hepatic stenosis, and distrurbing the adipokine regulation. Conclusion: there is significant correlation between ayurvedic an mo dern interpretation of ampact of alcoholism on fat metabolism integrative approach combining dietary management, detoxification, and lifestyle interventions are effective iun managing Medorog. Clinical Significance: The clinical relevance of *Varuni Madya Sevan* (alcohol drinking) is highlighted in this article as a major contributing factor to the disruption of fat metabolism that results in disorders such as obesity and fatty liver (*Medoroga*). It provides a deeper knowledge of how alcohol disrupts lipid pathways, increases the accumulation of toxins (*Ama*), and inhibits digestion (*Agni*) by bridging Ayurvedic and contemporary biological viewpoints. Through lifestyle changes, herbal therapy, and Ayurvedic cleansing, the study promotes integrative manage ment. Improvements in BMI, liver function, and metabolic health are demonstrated in documented case studies. This enhances Ayurveda's ability to provide evidence based, individualized treatment for metabolic diseases brought on by alcohol.