Abstract

Dr. Rishika Chauhan*, Dr. Amritanshu Saroch, Dr. Namisha Ramotra, Proff. Akhilesh Kumar Srivastava, Dr. Ajay Kumar Shukla

ABSTRACT

The concept of Vy?dhi­k?amatva, denoting the body’s natural and acquired ability to resist disease, occupies a pivotal place in Ayurvedic thought. Rather than limiting immunity to a single defensive mechanism, Ayurveda presents it as a dynamic and integrative phenomenon rooted in metabolism, tissue health, vitality, mental balance, and systemic regulation. Acharya Cakrap??i, in his commentary on the Charaka Sa?hit?, categorizes Vy?dhi­k?amatva into two distinct yet complementary dimensions—Vy?dhibalavirodhi and Vy?dhi-utp?da-pratibandhaka—which closely parallel adaptive and innate immunity in modern immunology. In contemporary biomedical science, immune competence is increasingly understood as being profoundly influenced by endocrine regulation. Hormones governing metabolism, stress adaptation, growth, sleep, and reproduction exert significant immunomodulatory effects. This article presents the classical Ayurvedic framework of Vy?dhi­k?amatva with authentic textual references and integrates it with modern immunological and hormonal perspectives, offering a holistic understanding of disease resistance.