World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN (O) : 2455-3301
ISSN (P) : 3051-2557
IMPACT FACTOR: 6.842

ICV : 78.6

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Abstract

EFFECT OF NASAPANA, PRACHANDABAIRAVA RASA AND PARAVAT KALPA OVER PRATIMARSHA NASYA, ARDHANGAVATARI RASA REGIMEN IN ISCHEMIC STROKE (MARGAAVARANA JANYA PAKSHAGHATA): A COMPARATIVE CLINICAL STUDY

*Dr. Pampanagouda Beemanagouda Katti, Dr. Fareeda Begum Shaikh

ABSTRACT

Introduction: Pakshaghata, one of the eighty Vata Nanatmaja Vyadhis, is characterized by unilateral paralysis and closely correlates with ischemic stroke in modern medicine. Sedentary habits, stress, hypertension, and diabetes have increased stroke incidence. In Margaavarana Janya Pakshaghata, the normal flow of Vata is obstructed by Kapha, resulting in stiffness, restricted mobility, and sensory loss. Ayurvedic management focuses on restoring Vata function through Snehana, Swedana, Nasapana, and Rasayana therapies. Aim: To evaluate the combined effect of Nasapana with Mashabaladi Kwatha, Prachanda Bhairava Rasa, and Paravat Kalpa over Pratimarsha Nasya with Mashabaladi Taila, Ardhanga Vatahari Rasa, and Paravat Kalpa in Margaavarana Janya Pakshaghata. Methods: An open-label randomized controlled clinical trial was conducted on 40 diagnosed cases of Pakshaghata, randomly allocated into two groups. Group A: Received Deepana-Pachana with Madhoodaka Pana, Sadyo Virechana with Payasa Eranda Taila, followed by Nasapana with Mashabaladi Kwatha, Prachanda Bhairava Rasa, and Paravat Kalpa. Group B: Received the same Deepana-Pachana and Virechana, followed by Pratimarsha Nasya with Mashabaladi Taila, Ardhanga Vatahari Rasa, and Paravat Kalpa. Both subjective and objective parameters were assessed before and after treatment. Results: Both groups showed statistically significant improvement in Pakshaghata symptoms. However, Group A exhibited superior gains in motor recovery, muscle tone, coordination, and sensory function. Conclusion: Nasapana with Mashabaladi Kwatha combined with internal medications offers better therapeutic outcomes than Pratimarsha Nasya. Its enhanced Dosha Shodhana, Agni Deepana, Ama Pachana, and Rasayana actions contribute to faster and more comprehensive recovery, highlighting the pivotal role of Panchakarma in managing Pakshaghata.

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