Abstract

Dr. Ashish Kumar Khatik*, Dr. Ramaling S. Hugar, Dr. Madhava Diggavi

ABSTRACT

Fatty Liver Disease (FLD), including Alcoholic and Non-Alcoholic types, is one of the most widespread chronic liver disorders globally. Non-Alcoholic Fatty Liver Disease, recently termed Metabolic Associated Fatty Liver Disease (MAFLD), is strongly linked with obesity, diabetes, dyslipidaemia, and metabolic syndrome. The condition may progress from simple steatosis to non-alcoholic steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. With a global prevalence of 25–30%, its incidence continues to rise due to sedentary lifestyle and unhealthy dietary patterns, increasingly affecting younger populations. Although early stages are often asymptomatic, FLD contributes significantly to liver-related morbidity and cardiovascular risk, emphasizing the importance of early diagnosis and effective management. Aim: To compare the therapeutic efficacy Snehapana with Purana Indukanta Ghrita, Virechana with Pathyadi Yoga, followed by Yakrutshoolvinashini Vati with Phalatrikadi Kashaya anupana, against Sharapunkha Kshara with Sharapunkha Kashaya in the management of FLD. Methodology: An open-labelled randomized controlled trial was conducted on 40 subjects with clinical features of FLD. Group A (n=20) received Deepana-Pachana for 3 days, Snehapana for 4 days, Vishrama Kala for 3 days, Virechana with Pathyadi Yoga, and then Yakrutshoolvinashini Vati with Phalatrikadi Kashaya for 34 days. Group B (n=20) received Sharapunkha Kshara with Sharapunkha Kashaya for 45 days. Results: Group A showed superior improvement in subjective parameters such as Aruchi, Daurbalya, and VAS pain score, while Group B provided slightly better relief in right upper quadrant pain. Objective findings revealed highly significant improvement in fatty liver grade, HDL, bilirubin, SGPT, and triglycerides in Group A, whereas Group B showed better reduction in total cholesterol and LDL. Conclusion: FLD, correlated with Yakrutgata Medoroga, primarily results from Kapha-Meda Dushti and Agnimandya. Combined Shodhana and Shamana therapy demonstrated substantial clinical and biochemical improvement, indicating its efficacy in restoring hepatic function.