REVIEW ON SOLID DISPERSION-BASED FAST DISSOLVING TABLETS FORMULATION APPROACHES AND EVALUATION
Aakash Prajapati*, Priyanka Yadav, Amar Raval, Jaini Patel
ABSTRACT
Solid dispersion-based fast-dissolving tablets (SD–FDTs) are an emerging oral delivery platform designed to overcome the twin challenges of poor aqueous solubility and patient non-compliance. This technology integrates the solubility enhancement properties of solid dispersion (SD) systems with the rapid disintegration capability of fast-dissolving tablets (FDTs). This approach promotes molecular-level dispersion of hydrophobic drugs within hydrophilic matrices, improving wettability, surface area, and dissolution rate while minimizing crystallinity. Recent research emphasizes hot-melt extrusion, spray drying, and co-amorphous systems for stable SD formation and direct compression or lyophilization for tablet fabrication. Carriers such as PVP, HPMC, Soluplus®, and PEG have demonstrated improved dissolution and stability. The review outlines theoretical principles, preparation strategies, formulation design, physicochemical evaluation, and emerging technological advances, providing an in-depth analysis of how SD–FDTs can bridge the gap between formulation science and patient-centric drug delivery.
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