World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN (O) : 2455-3301
ISSN (P) : 3051-2557
IMPACT FACTOR: 7.533

ICV : 78.6

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SJIF Impact Factor: 7.533

Abstract

A REVIEW ON NATURAL KILLER CELLS (NK) IN CANCER

Poonam Goswami, Povel V. Modi, Parthiv Patel, Arpit Patel, Hiren Makwana, Niyati Nayak, Ms. Divya Mahyavanshi*

ABSTRACT

Natural killer (NK) cells represent a critical component of the innate immune system with potent anti-tumor capabilities. These cytotoxic lymphocytes provide rapid, MHC-unrestricted responses against malignant cells, making them attractive candidates for cancer immunotherapy. This review explores the fundamental biology of NK cells, their role in cancer surveillance and elimination, mechanisms of tumor evasion, and the rapidly evolving landscape of NK cell-based therapeutic strategies. We discuss current clinical applications, emerging technologies including chimeric antigen receptor (CAR)-NK cells, and future directions in harnessing NK cell biology for oncological treatment.

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