World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN (O) : 2455-3301
ISSN (P) : 3051-2557
IMPACT FACTOR: 7.533

ICV : 78.6

World Journal of Pharmaceutical and Medical Research (WJPMR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Indian Science Publications , Cosmos Impact Factor , Research Bible, Fuchu, Tokyo. JAPAN , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , International Innovative Journal Impact Factor (IIJIF) , Scientific Journal Impact Factor (SJIF) , Global Impact Factor (In Process) , Digital Online Identifier-Database System (DOI-DS) , Science Library Index, Dubai, United Arab Emirates , Eurasian Scientific Journal Index (ESJI) , International Scientific Indexing, (ISI) UAE , IFSIJ Measure of Journal Quality , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , Doi-Digital Online Identifier , ISSN National Centre , Zenodo Indexing , International CODEN Service, USA , 

Abstract

TARGETING INFLAMMATION AND OXIDATIVE STRESS IN OCULAR DISEASE WITH A MULTI-COMPONENT NUTRITIONAL INTERVENTION

Suman Subramanian, Karthikeyan Periyasami, Moulishankar Sundararajan, S. Sridhar, Raaja George Nadar, Aathithiah Gopalakrishnan Sarada, Vetriselvan Murugasan, Joemon Jose Radhika, Pachiyappan Ramasamy, Devendran Balasubramani, Arunothayam Manoh

ABSTRACT

Purpose: Age-related ocular disorders such as cataracts, glaucoma, and age-related macular degeneration (AMD) are major causes of visual impairment, especially in individuals over 40. These conditions are driven by multifactorial mechanisms, including oxidative stress and chronic inflammation. This study evaluates the efficacy and safety of EverBrite, a novel nutraceutical formulation containing lutein, zeaxanthin, DHA, EPA, vitamins C and E, zinc sulphate monohydrate, and Vaccinium myrtillus (bilberry) extract, designed to address multiple pathogenic pathways in ocular disease. Methods: A Phase I randomized controlled trial was conducted with 10 participants diagnosed with ocular conditions such as dry eye syndrome, conjunctivitis, photophobia, ocular allergies, and viral infections. Participants received the EverBrite formulation daily for 30 days. Clinical outcomes were assessed through symptom scoring and physician-observed ocular health improvements. Results: In a pilot clinical study, 70% of participants experienced clinically meaningful improvements, especially those with acute and chronic conjunctivitis. Over two years of real-world use following its release, the formulation has continued to deliver consistent benefits, including reduced eye inflammation, discharge, and discomfort. It has also been well tolerated, with no adverse effects reported. Conclusions: These preliminary results suggest that the EverBrite formulation may offer a safe and effective adjunctive strategy for managing age-related and inflammatory ocular disorders. These studies confirm the findings and explore the formulation’s impact on supporting eye health.

[Full Text Article]    [Download Certificate]

Powered By WJPMR | All Right Reserved

WJPMR