FORMULATION AND IN-VITRO EVALUATION OF CRYPTOLEPIS BUCHANANI’S EXTRACT LOADED EMULGEL
Meenakshi Verma, Jyoti Sharma, Pankaj Bhateja, Mona Piplani*
ABSTRACT
This study presents the formulation and in vitro evaluation of an emulgel containing extract of Cryptolepis buchanani’s, a medicinal plant recognized for its significant anti-inflammatory, antibacterial and antioxidant properties. Emulgels, which combine the benefits of emulsions and gels, offer a suitable delivery system for poorly water-soluble herbal compounds. Ethanolic extracts of C. buchanani leaves were prepared and incorporated into an oil-in-water emulgel base using Carbopol 940 as the gelling agent. The formulations were optimized for physicochemical parameters including pH, viscosity, spreadability, homogeneity and stability. Various formulations of the extract were evaluated to identify the most effective and stable composition. The optimized formulation displayed favorable characteristics, with an ideal pH range (5.8–6.5), desirable viscosity and excellent spreadability, indicating its suitability for topical application. Drug release studies revealed a sustained release profile over 8 hours.These findings highlight the potential of the C. buchanani based emulgel as a promising alternative for the treatment of inflammation. The study demonstrates the effective integration of traditional herbal medicine with modern pharmaceutical delivery systems, offering probability of enhanced therapeutic potential and patient compliance. Further antimicrobial study and in vivo studies are recommended to substantiate the therapeutic efficacy and safety of this novel formulation in clinical settings.
[Full Text Article] [Download Certificate]