Abstract

Parmar Kamakshi, Patel Annavi, Patel Ayushi, Pandit Hetvi, Rathod Pranjalba, Patel Jaini*

ABSTRACT

These comprehensive studies highlight the formulation and evaluation of herbal suppositories aimed at improving rectal drug delivery. Suppositories are solid matrix dosage forms that melt at body temperature and are good alternatives to oral medicines, particularly if the patients suffer from problems such as vomiting, nausea, or difficulty in swallowing or when drugs undergo extensive first-pass metabolism. The study was carried out by formulating seven distinct formulations (F1-F7) based on glycerinated Gelatin, followed by evaluation of weight variation, friability, hardness, disintegration time, and in vitro drug release. The experimental results demonstrated that the suppositories had excellent pharmaceutical properties, with weight variation within the acceptable pharmacopeial limit of ±5%, friability below 0.35%, and an immediate disintegration time of 9–10 minutes. And release was found to be more than 95% in 23 min by dissolution studies, indicating good drug delivery. This result validly proved that flaxseed suppositories are natural, safe, and effective preparations to be used for constipation, Hemorrhoids, and gastrointestinal problems and represented the integration of folk wisdom with rational therapeutic concepts, which will have greater value for patient care.