Abstract

Gupta Sahil*

ABSTRACT

Background: Alpha-Gal Syndrome (AGS) is an emerging allergic disorder characterized by a delayed hypersensitivity reaction to mammalian meat and dairy proteins, caused by IgE antibodies against galactose-α-1,3-galactose (α-gal). Alpha-gal is a carbohydrate epitope present in mammalian meat. The condition manifests with urticaria, various gastrointestinal disturbances, and systemic allergic symptoms, often appearing hours after ingestion (typically after 3-6 hours). Not all patients with clinical features of Alpha-Gal Syndrome (AGS) test positive for Alpha-gal IgE antibodies. This highlights Alpha-Gal syndrome (AGS), where immune sensitization may be present but undetectable by conventional assays, possibly due to a delayed IgE response, low circulating titers, or immune tolerance mechanisms. From an Ayurvedic perspective, such presentations correspond to Sheetpitta and Krimi Roga manifestations, where systemic hypersensitivity occurs independent of measurable antibody levels. Objective: While management of AGS (Alpha-Gal syndrome) is largely limited to dietary restriction, Ayurveda offers a more comprehensive approach. To present the Ayurvedic management of a patient with suspected AGS, highlighting correlations with Sheetpitta, Ahara Asatmyata (food incompatibility), and Krimi Roga (gut microbial or immune dysregulation), and to demonstrate the potential of Ayurvedic therapy in restoring digestive-immune balance. Materials and Methods: A 56-year-old female presented with recurrent urticaria, nausea, vomiting, and hypersensitivity to mammalian foods and cooking fumes. Despite elevated total IgE, Alpha-gal IgE was negative. Ayurvedic assessment identified Sheetpitta and Ahara Asatmyata with an underlying Krimi Roga tendency, suggesting gut dysbiosis and immune overactivation. Treatment included Durva Swaras, Aahar Amrutham Capsules, Anthra Mithram Gulika No. 2, Triphala, and Bhoomi Amla, along with diet and lifestyle modifications. The patient also has a history of type 2 diabetes. Results: By six weeks, significant improvement in urticaria, gastrointestinal symptoms, and energy levels was noted. At three months, accidental meat consumption did not trigger hypersensitivity, suggesting improved tolerance. Clinical remission persisted despite intercurrent COVID-19 infection. Although there is mild constipation with Anthra Mithram Gulika No. 2 and Durva capsule. Conclusion: This case explained that AGS may conceptually align not only with Sheetpitta, Aahara Asatmayta, but also with Krimi Roga, reflecting gut dysbiosis and immune hyper-reactivity. This case also helps to understand that AGS may occur when the Alpha-Gal Syndrome (AGS) test is negative. Ayurvedic treatment achieved both symptomatic resolution and systemic correction, demonstrating Ayurvedic treatment value for food-induced hypersensitivity disorders.