ANTI-HYPERGLYCEMIC ACTIVITY AND ISOLATED COMPOUNDS OF TUBERS OF ICACINA OLYVIFORMIS (POIRET) RAYNAL (ICACINACEAE)
Armel Diatta, Anastasie Manga, Mbaye Diagne Mbaye, Oumar Sambou, Abdoulaye Gassama*, Catherine Lavaud
ABSTRACT
Icacina oliviformis (pear) raynal (Icacinaceae) is Senegalese traditional pharmacopoeia plant, whose tubers are used in the treatment of various diseases, in particular diabetes. The ethalonic extract of Icacina oliviformis tubers showed anti-hyperglycemic activity in models of temporary hyperglycemia. The tests were carried out in normoglycemic rats, on a glucose tolerance test. The phytochemical study of the tubers enabled us to isolate from the cyclohexanolic and ethanolic extracts of Icacina oliviformis respectively six (06) clerodane-type diterpenes and one pymarane-type diterpene (compounds 1-7), all of them are known. The isolated compounds were characterized by NMR and mass spectrometry. This study is one of the first phytochemical examinations of the tubers and anti-hyperglycemic activity of the ethanolic extract of Icacina oliviformis.
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