World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN (O) : 2455-3301
ISSN (P) : 3051-2557
IMPACT FACTOR: 6.842

ICV : 78.6

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Abstract

ANTI-HYPERGLYCEMIC ACTIVITY AND ISOLATED COMPOUNDS OF TUBERS OF ICACINA OLYVIFORMIS (POIRET) RAYNAL (ICACINACEAE)

Armel Diatta, Anastasie Manga, Mbaye Diagne Mbaye, Oumar Sambou, Abdoulaye Gassama*, Catherine Lavaud

ABSTRACT

Icacina oliviformis (pear) raynal (Icacinaceae) is Senegalese traditional pharmacopoeia plant, whose tubers are used in the treatment of various diseases, in particular diabetes. The ethalonic extract of Icacina oliviformis tubers showed anti-hyperglycemic activity in models of temporary hyperglycemia. The tests were carried out in normoglycemic rats, on a glucose tolerance test. The phytochemical study of the tubers enabled us to isolate from the cyclohexanolic and ethanolic extracts of Icacina oliviformis respectively six (06) clerodane-type diterpenes and one pymarane-type diterpene (compounds 1-7), all of them are known. The isolated compounds were characterized by NMR and mass spectrometry. This study is one of the first phytochemical examinations of the tubers and anti-hyperglycemic activity of the ethanolic extract of Icacina oliviformis.

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