World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN (O) : 2455-3301
ISSN (P) : 3051-2557
IMPACT FACTOR: 6.842

ICV : 78.6

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SJIF Impact Factor: 6.842

Abstract

FORMULATION AND EVALUATION OF SALICYLIC ACID AND KOJIC ACID AS GEL NOVEL DRUG DELIVERY SYSTEMS FOR TREATMENT OF ACNE AND WHITENING SKIN EFFECT

Abdalwali Ahmed Saif, Maged Alwan Noman, and Mahmoud Mahyoob Alburyhi*

ABSTRACT

The aim of this study was to formulate and develop a gel containing salicylic acid and kojic acid for the treatment of acne and skin lightening. This preparation contains active ingredients that give the best results for the skin. Five gel formulations were evaluated for various parameters such as color, appearance, consistency, pH, viscosity, applicability, irritancy test, and stability studies. The results showed that the gel was non-irritant, stable, and possessed activity in treating acne and skin lightening. Formulation F4 was found to be the best due to its balanced viscosity, ideal pH, ease of application, and excellent clinical performance. We conclude that the gel containing salicylic acid and kojic acid prepared considered an effective and safe formulation for treating acne and skin lightening.

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