Abstract

Ananya P. V.*, Krishnananda Kamath K., A. R. Shabaraya

ABSTRACT

The conventional dosage form like tablet and capsule has wide acceptance. Research has done to prepare Naproxen fast dissolving tablets of Naproxen by Hole Technology. Once these fast- dissolving tablets contact with gastro intestinal fluids, the fluid can enter the hole within the tablet and immediate disintegration of tablets will takes place. Fast dissolving tablets of Naproxen was designed with a view to provide a quick onset of action. Here fast dissolving tablets were prepared by direct compression by using super disintegrates such as Sodium Starch Glycolate and Croscarmellose Sodium etc. This quick disintegration of tablets is additionally influenced by the formation of latest absolute space. The ready FTDs were subjected to numerous pre and post formulation studies. Its disintegration and dissolution rates were compared. Evaluation parameters like hardness and friability indicates that the tablets were mechanically stable in all formulations. Among the four formulations, F3 exhibited the highest drug release 98.29% in 30 minutes and was identified as the optimum formulation. The findings confirm that Hole Technology is an effective approach to increase tablet porosity, thereby improving drug solubility and dissolution. Naproxen fast dissolving tablets prepared by hole technology using camphor as a sublimating agent shows excellent drug release from the tablet so it shows that this method increases the porosity of the tablet and it is the one of the best methods used for the preparation of fast dissolving tablets.