Abstract

*Sowndarya R, Sabreen Z, Suganthi R

ABSTRACT

The convergence of bioelectronics, smart sensing, and embedded computation is ushering in a new era for drug delivery systems that not only sense and respond in real time, but actually “remember” patient history to adapt therapy over the long term. These memory-guided drug delivery implants promise to transform chronic disease management by pre-empting episodes, minimizing side effects, and tailoring treatments to dynamic, highly individual physiological patterns. Here, we critically review the state of the art behind these systems, spanning implantable sensors, biocompatible logic and memory circuits, adaptive drug-release mechanisms, and real-world clinical examples. We also discuss the challenges - both technical and ethical—that must be tackled for broad adoption, and we look ahead to a future where on-device artificial intelligence personalizes medicine as never before.