ISOLATION AND STRUCTURAL ELUCIDATION OF THREE NEW COMPOUNDS FROM THE AERIAL PARTS OF CROTON GÉAYI LÉANDRI (EUPHORBIACEAE), ENDEMIC TO MADAGASCAR. BIOLOGICAL STUDIES
Ratiankavana Benjamin Larios Princis*, Ralaivaon-Dratsitonta Jumael Edith Fabrice,
Tiandreny Hazara Jipaty, Andrianarijaona Mamy, Fienena Raymond François, Fiatoa Barthelemy, Fatiany Pierre Ruphin
ABSTRACT
The genus Croton is involved in several medicinal applications. The species Croton geayi Léandri, endemic to southern Madagascar, exhibits antimicrobial and vasorelaxant activities. Chemical studies conducted on the aerial parts of this plant led to the isolation of three novel compounds: two, designated LCB-01 and LCB-02, belonging to the iridoid family, which inhibit bacterial activity; and a third, designated LCB-03, belonging to the indole alkaloid family, which acts as a vasorelaxant. The structures of these three molecules were elucidated using mass spectrometry and 1D and 2D NMR spectroscopy.
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