Abstract

Mahmoud Mahyoob Alburyhi*, Salwa M. Raweh, Abdul Basit Ahmed Al Ghoury, Mohammed A. Al Khawlani, Maged Alwan Noman and Abdalwali Ahmed Saif

ABSTRACT

The objective of this present study was to produce an ointment formulation containing an Grewia tenax extract and evaluate its antimicrobial activity. Grewia tenax (Family:Tiliacea) represent as one of the selected plants used as treatment. The alcoholic extract of different part of plant (leaves, stems and fruits) were have antimicrobial effects against different tested microorganisms at different concentrations. The results indicated that the alcoholic leaves extract was more efficacy against tested microorganisms (S. aureus, S. epidermidis, E. coli and P. aeruginosa) with inhibition zones equal (18,19,17and14mm) respectively than other parts extract followed by stem extract then by fruits extract with the inhibition zones (17,18,17, and 13mm) and (17,16,15 and 14mm) against (S. aureus, S. epidermidis, E. coli and P. aeruginosa) respectively. Generally, the antibacterial activity of Grewia tenax extract appears to be inhibitory to Gram-positive bacteria more than Gram-negative bacteria. The ointment formulations were prepared which are concentrations (12.5, 6.25, 3.125 and 1.5% w/w) and made compare between base and ethanol extract were evaluated. The formulation ointment containing F1(12.5w/w) extract showed better antimicrobial activity, physicochemical characteristics, and pharmacological parameters than the other ointment formulations. The zone of Gentamycin was similarity with a highly concentration ointment formulation F1(12.5w/w) were evaluated. Among the all-ointment formulations the ointment formulation F1(12.5w/w) containing Grewia tenax showed better antimicrobial activity. It was concluded that the extract of Grewia tenax F1(12.5w/w) was a better candidate for nutraceutical delivery systems of antimicrobial agents for eradicating common microbial infections.