World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN (O) : 2455-3301
ISSN (P) : 3051-2557
IMPACT FACTOR: 6.842

ICV : 78.6

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Abstract

COMPLICATED CHRONIC SILICOSIS: A THERAPEUTIC CHALLENGE – A CASE REPORT

H. Arfaoui, *S. Moumni, W. El Khattabi, C. Belhaj S. Msika, H. Bamha, N. Bougteb and M. H. Afif

ABSTRACT

Silicosis is an occupational lung disease caused by inhalation of respirable crystalline silica dust, typically encountered in industrial activities. We report a case of a 40-year-old dental technician with 18 years of silica exposure and occasional hookah use. The disease presented with worsening dyspnea over three months, progressing to mMRC stage III. Chest CT showed bilateral reticulonodular infiltrates, traction bronchiectasis, and calcified “egg-shell” mediastinal lymphadenopathies. Bronchoscopy and transbronchial biopsies were non-specific. The sarcoidosis work-up was negative. Multidisciplinary discussion concluded a diagnosis of silicosis. The patient was started on long-term oral corticosteroids. The disease progressed with worsening fibrosis and declining pulmonary function. Nintedanib was initiated following multidisciplinary review. After two months, the patient showed clinical improvement..

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