Abstract

Mahmoud Mahyoob Alburyhi* and Amina El-Shaibany

ABSTRACT

Diabetes is a serious health concern in many countries with high blood glucose, obesity, and multiple organ failures in late stages. Treating diabetes with effective drugs is still a challenging issue since most of the available diabetic drugs are not effective in combating diabetes, especially in secondary disease complications like obesity retinopathy, and nephropathy associated diabetes. Hence search for effective anti-diabetic medication, especially from natural sources is mandatory with no adverse side effects. Ginger (Zingiber officinale) is a plant widely used all over the world. A flowering plant known as ginger is utilized for both culinary and medicinal purposes and traditional healing. Ginger (Zingiber officinale), a spice used in Chinese and Ayurvedic traditions to treat diseases ranging from gingivitis to asthma, contains many antioxidant compounds that are thought to exert strong anti-inflammatory effects by inhibiting cyclooxygenase, inducible nitric oxide synthase, and lipoxygenase, as well as suppressing prostaglandin synthesis. Ginger is rich in bioactive components that promote the prevention and treatment of chronic conditions like heart disease, cancer, and Type 2 diabetes, are inexpensive and have no side effects. A Ginger was formulated as capsules and evaluated for organoleptic properties and other evaluation parameters. It was concluded that among the all formulations of Ginger extract capsules the F1 was found to be as an optimized capsules according to drug release percentage 96% within 60 minutes, so the F1 was the best formulation of Ginger extract capsules delivery system as an advanced phytotherapy approach for controlling diabetes.