Abstract

Deepthi Mathew*, Dr. Sunbee Prakash, Dr. Santhosh M. Mathews and Dr. I. John Wesley

ABSTRACT

Microsponges are porous, polymeric microspheres that are used chiefly for topical and recently, oral administration. Ketoprofen was used as a model drug for systemic drug delivery of microsponges in the study. Ketoprofen microsponges were prepared by the quasi-emulsion solvent diffusion method with Eudragit RS 100, and afterwards, microsponges were used as different dosage forms. Microsponges can gradually release a certain quantity of medication over time in reaction to various factors. Consequently, the chemical and physical characteristics of the active agents and microsponges must be taken into account during the development process. The dimensions and quantity of interconnect channels in microsponges, along with the drug delivery characteristics, can be influenced by the interaction between their physical properties and the polymer(s) utilized in their preparation. Microsponges have a plastic property that allows for direct compression, resulting in a tablet with greater mechanical strength than a mixture of active agent and polymer alone.There is currently a very promising method for oral medication delivery that increases the rate of poorly soluble drug release by entrapping into microspongepore system.