Abstract

Sanjay Lade* and Dr. Dwivedi Jayesh

ABSTRACT

The increased resistance of bacteria against conventional pharmaceutical dosage forms, the antibiotics, has raised serious health concerns. This has stimulated interest in the development of bio-based therapeutics with limited resistance, namely, proteins, enzymes, and peptides having antibacterial activity. This study envisaged the evaluation of the antimicrobial efficacy of selected biomolecules formulations, namely Lysozyme 1mg tablet and Lysozyme powder for oral solution 1mg/mL against bacteria commonly associated to nosocomial infections: Staphylococcus aureus. The antibiotic Streptomycin tablet was used as control compounds for comparison purposes. The sensitivity testing of the Lysozyme powder for oral solution 1mg/mL and Lysozyme 1mg tablet were done using the agar well diffusion method. The antibacterial activity of lysozyme can be attributed to its ability to hydrolyze the peptidoglycan layer of bacterial cell walls, leading to cell lysis and death. The results support the potential use of lysozyme powder for oral solution and Lysozyme 1mg tablet for managing mild antibacterial infection particularly those involving gram-positive bacteria.