Abstract

Shruti Parshuramkar, Priya Sahare, Prof. Dr. Ranju Pal Girhepunje, Prof. Dr. Kundlik Girhepunje*

ABSTRACT

Osteoarthritis (OA) is a degenerative inflammatory condition of the joint cartilage that currently affects approximately 58 million adults in the world. It is characterized by pain, stiffness, and a reduced range of motion with regard to the arthritic joints. These symptoms can cause in the long term a greater risk of overweight/obesity, diabetes mellitus, and falls and fractures. Although the current treatment of OA is characterized by non-steroidal anti-inflammatory drugs (NSAID), opioids, and cyclooxygenase (COX-2-specific) drugs, this may affect a variety of vital organs with long-term use so nowadays great interest has been applied to nutraceutical supplements, which include a heterogeneous class of molecules with great potential to reduce inflammation, oxidative stress, pain, and joint stiffness and improve cartilage formation. The purpose of this review is to describe the potential application of nutraceuticals in OA, highlighting its mechanism.