Abstract

Priyanka Kumari*, Sk Sakil and Ranjan Kumar Maji

ABSTRACT

The objective of this project is to create an orally disintegrating tablet that contains rizatriptan benzoate uti lizing a natural superdisintegrant by direct compression. The concentration of superdisintegrants, such as sodium starch glycolate (SSG), Ac Di Sol, crosspovidone (CP), Spray dried lactose, and microcrystalline cellulose (MCC), should be considered when pr eparing MDDs with rizatriptan benzoate using direct compression. These superdisintegrants can be used alone or in various combinations, along with mannitol, lubricant, and glidants. The aim of this study was to create MDDs (multilayered drug delivery syste ms) that have a rapid disintegration time, strong mechanical properties, high patient compliance, and a stable profile. This was achieved by using various preparation methods and investigating different factors that influence the pre and post compression p arameters of rizatriptan benzoate formulas. The combination of agents exhibits enhanced disintegrating properties as a result of their quick water absorption and dispersion time, leading to accelerated drug release and faster disintegration. The findings o f the release kinetics investigation demonstrated that all the formulations adhered more closely to a first order drug release profile, meaning that the rate of release was dependent on the starting concentration of the medication.