Abstract

Ramaswami Deepankar, Gopal Rai, Shuchi Dave*

ABSTRACT

Cnidoscolus phyllacanthus, commonly known as faveleira, is a drought-resistant shrub plant. It belongs to the Euphorbiaceae family and thrives in arid regions. The plant has spiny stems, lobed leaves, and produces small white flowers. Its seeds are rich in oil, making them valuable for biodiesel production. Faveleira is also used as fodder for livestock due to its high nutritional content. This study seeks to determine the anti-inflammatory of Cnidoscolus Phylanthus medicinal plant that have been used traditionally to treat inflammation. The present study was undertaken to determine anti-inflammatory of Cnidoscolus phyllacanthus using various biochemical parameter. Preparation of Hydroalcoholic extract hot percolation method where obtained % yield as 2.67 % which was brown in color and semi-solid in consistency. Oral Acute toxicity study was evaluated as per OECD guidelines (425) on Wistar albino rats, where three dose levels 100 mg/kg, 200 mg/kg & 300 mg/kg was selected for anti- inflammatory activity. The qualitative phytochemical test was performed for the assessment of the presence of phytoconstituents where the preliminary phytochemical analysis indicated a positive reaction for the presence of coumarins, flavonoids, carbohydrates and anthracene derivatives in Hydroalcoholic extract of Cnidosolus Phyllacanthus whereas negative reaction with proteins, amino acids, tannins, alkaloid, and sterols. Anti-inflammatory activity by carrageenan rat paw edema method and Histamine-induced paw edema Method which exhibits anti-inflammatory properties by reducing paw edema in a dose-dependent manner.