Abstract

Aravinda Nalla* and Krishna Mohan Chinnala

ABSTRACT

The present work is to formulate and evaluate the ointment of garlic bulb extract for anti-microbial activity. The benzene extract was prepared by Soxhalation method. The ointment base was prepared and four formulations of ointments were done by incorporating the extract in the base by levigation method. All the formulations were evaluated for their physicochemical parameters like colour, odour, pH, spreadability, extrudability, consistency, diffusion study, solubility, washability. Also the formulation was evaluated for its stability at various temperature conditions which shows no change in the irritancy, spreadability and diffusion study. From four ointments, F4 was found to be the best formulation as it shows 98% drug release within 6hours, drug content 98.8% and it shows more zone of inhibition against Bacillus as compared to other three formulations.