Abstract

*Padmashree V. and Sudha B. S.

ABSTRACT

Atorvastatin calcium belongs to class of HMG-COA reductase inhibitors. It is one of the commonly used anti-hyperlipidemic drug for the treatment of hyperlipidemia. It is a BCS class II drug (low solubility and high permeability). Its bioavailability is low due to poor aqueous solubility. The objective of this work is to prepare and evaluate Atorvastatin calcium loaded lipospheres for sustained release of drug. The optimized Atorvastatin calcium loaded lipospheres were later compressed into tablet and compared with marketed product. Stability studies are conducted suitably for optimized lipospheres. Atorvastatin calcium loaded lipospheres was prepared using stearic acid and soyabean-phosphatidylcholine(soya-lecithin) as a core and coat by melt-dispersion method. The formulation F-14 was found to be the better formulation, thus considered as optimized and it is further compressed to tablet. The obtained results suggested that a lipospheres are potentially promising formulation for the efficient delivery of poorly water-soluble drugs by oral drug delivery system. The prepared lipospheres proved to be potential for oral sustained drug delivery.