Abstract

Jyoti Narvariya*, Shonu Jain, Anjali Singh and Rashmi Haldkar

ABSTRACT

The patients with sudden increase blood pressure have markedly reduced function ability and extremely restless, in such cases rapid onset of action is of prime importance. So the patients would be benefited from acute treatment by using fast dissolving drug delivery system. Trandolapril (TD) is an anti-hypertensive drug which is insoluble in water; hence the drug may be slowly or incompletely dissolves in the gastro-intestinal tract. So the rate of dissolution and therefore its bioavailability is less (bioavailability 4-14%). The aim of the present work is to develop fast dissolving tablets from the solid dispersion of TD for enhancement of solubility. The solid dispersions of TD were prepared with PEG 4000, PVP K-90 in 1:1, 1:2 and 1:3 by using conventional method. The prepared solid dispersions were analyzed for all the physical parameters, drug: carrier interactions like FTIR. Solid dispersions showed a better dissolution compared to the pure drugs and among all the other formulations F3 shows high percentage drug release i.e. 39.98 % for 240 min and selected as an optimized formulation for the preparation of fast dissolving tablets of TD. Sodium starch glycolate, croscarmellose sodium used in the preparation of fast dissolving tablets prepared by direct compression method. The post compression parameters of all the prepared tablets were within the limits. F4 was selected as optimized formulation based on its highest disintegration time 60sec and drug release 89.98% for 15 min. Drug-excipients characterization also revealed that there is no interaction. Hence it concluded that solid dispersions incorporated fast dissolving tablets is very useful approach for immediate release of TD in the efficient management of hypertension.