Abstract

Ananya Chandel*, Ankit Sharma, Dhiraj Kumar, Samriti Sharma, Deepti Sharma and Kamlesh Thakur

ABSTRACT

Pharmacovigilance is the science that deals with the study of adverse effects associated with a particular drug. Proton pump inhibitors (PPI) are drugs that are used in the management of gastric acid-related disorders, seeing as how their introduction to the market in 1999. These drugs have a mechanism of action based on the last step of gastric acid secretion by a peripheral cell and very few, mostly tolerable adverse effects. However, the use of PPI may lead to long-term adverse effects, including liver infection, an increased risk of kidney disease, dementia, cardiovascular disease, enteroendocrine tumors of the GIT, and respiratory, gastrointestinal, and respiratory infections. It is very important to raise new questions about PPI safety profiles and their clinical indications. Thus, the main aim of this review is to assess the worth of the concern about the association between the use of PPI and the risk of serious adverse effects.