Abstract

Ayman Fakhry, MD.* and Sohiel Nagib, MSc., EFVS

ABSTRACT

Background: Venous ulcers are characterized by a cyclical pattern of healing and recurrence.[1] The current standard of care for chronic venous ulcers involves the use of compression bandages as a means to reduce ambulatory venous pressure, control edema, and improve venous return. Dressings are applied beneath the compression and are used to control the exudates and to maintain the wound in a moist environment. Since the 1960s it has been accepted that wound healing is optimal when the wound is kept in a moist environment rather than air dried.[2] Objective: Detection of the safety and efficacy of (ZYMALGE GEL) versus standard dressing for the treatment of chronic venous ulcers. Patients & Methods: 40 patients were admitted to the Royal vascular center, with chronic venous ulcer, from 1st January 2023 – 31st December 2023, and randomly classified into 2 groups. - Group A) comprised 20 patients, treated with (ZYMALGE GEL), and compression. - Group B) comprised 20 patients, treated with (traditional dressing) and compression. The primary end point was determined as complete wound healing within 3 months of treatment with or without correction of arterial or venous insufficiency. Results: Age ranged from 29-63 years and x age 39.8+0.6 years in group A patients and29-63 years and x age 39.8+0.6 years in group B patients. Complete wound healing was observed in 20 patients 100% with a mean duration of 6.03+ 0.8 weeks in group A patients, while only 15 patients 75% gained complete healing within the previously determined duration (3 months), with a mean duration of 9.01+ 0.4 weeks in group A patients. Conclusion: Zymalge gel (combination of antimicrobial enzymes, hyaluronic acid, alginate, and moisture agent) is a safe and effective topic treatment for venous ulcer especially when combined with compression, and management of arterial and venous insufficiency.